EXPLORE Labs - Stem Cell Research
Stem Cell Research, Edmonton, Alberta

Project #1 Lung Angiogenesis

Lung Angiogenesis

Publications:

- Vadivel A, Abozaid S, Haaften T, Sawicka M, Eaton F, Chen M, Thébaud B. Adrenomedullin promotes Lung Angiogenesis, Alveolar Development and Repair. Airway Delivery of Mesenchymal Stem Cells prevents Arrested Alveolar Growth in Experimental Neonatal Lung Injury. Am J Respir Mol Cell Biol 2009

- Thébaud B, Abman SH. Bronchopulmonary Dysplasia-Where Have all the Vessels Gone? Am J Respir Crit Care Med. 2007

- Thébaud B, Ladha F, Michelakis E, Sawika M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. VEGF Gene Therapy Increases Survival, Promotes Lung Angiogenesis and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury: Evidence that Angiogenesis participates in Alveolarization. Circulation 2005

- Ladha F, Bonnet S, Eaton F, Hashimoto K, Korbutt G, Thébaud B. Sildenafil Improves Alveolar Growth and Pulmonary Hypertension in Hyperoxia-Induced Lung Injury. Am J Respir Crit Care Med 2005

Project #2 Stem Cells

Stem Cells

Publications:

- van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, GJ Rey-Parra, Bouchentouf M, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. Airway Delivery of Mesenchymal Stem Cells Prevents Arrested Alveolar Growth in Neonatal Lung Injury in Rats. Am J Respir Crit Care Med 2009

- van Haaften T, Thébaud B. “Adult bone marrow-derived stem cells for the lung: Potential implications for pediatric lung diseases”. Pediatr Res, 2006

Project #3 Lung Development, Injury and Repair

Lung Development, Injury and Repair

Publications:

Alphonse RS, Coltan L, Eaton F, Barr AJ, Dyck JRB, Thébaud B. Activation of Akt Protects Alveoli from Oxygen-induced Lung Injury. Am J Respir Mol Cell Biol 2010

Project #4 Lung Hypoplasia and Pulmonary Hypertension

Pulmonary Hypertension

Publications:

- Van der Horst I, Morgan B, Eaton F, Reiss R. Tibboel D, Thébaud B. Expression and function of phosphodiesterases in experimental nitrofen-induced congenital diaphragmatic hernia in rats. Pediatr Pulmonol 2010

- Babiuk RP, Thébaud B, Greer J. Reductions in the incidence of nitrofen-induced diaphragmatic hernia by vitamin A and retinoic acid. Am J Physiol 2004

- Greer J, Babiuk RP, Thébaud B. Etiology of congenital diaphragmatic hernia: The retinoid hypothesis. Pediatr Res 2003;53:726-30

- B Thébaud, AM Barlier-Mur, B Chailley-Heu, A Henrion-Caude, D Tibboel, AT Dinh-Xuan, JR Bourbon. Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med 2001

- B Thébaud, D Tibboel, C Rambaud, J-C Mercier, JR Bourbon, AT Dinh-Xuan, SL Archer. Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol 1999

Lung Hypoplasia